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Details of talk

TitleHow does pressure within a tumour affect the outcome of cancer treatment?
PresenterAdrianne Jenner (University of Sydney)
Author(s)Adrianne Jenner
SessionMathematical Biology
Time14:00:00 2017-09-26

Interstitial pressure or elevated pressure within tumours has been identified as
one of the major culprits impeding effective cancer treatments such as
immunotherapy. Tumour pressure is known to cause heterogeneous intratumoural
distribution of cancer treatments and increase the metastatic potential of
tumours. Reducing tumour pressure has been shown experimentally to enhance the
uptake of therapies as well their homogeneous distribution. So how instrumental
is tumour pressure in reducing treatment efficacy? In this work we model the
spatial distribution of treatment and the effect of pressure on treatment
diffusibility. We use an off-lattice agent based approach to model this problem.
Investigations are undertaken into the optimisation potential of pressure
reducing treatments combined with alternate treatment application profiles to
discern how to enhance homogeneous treatment diffusion without allowing the
formation of metastasis. This work addresses an area possibly lacking in
investigation and through deriving an appropriate mathematical model we show the
impact of tumour pressure on immunotherapy and cancer treatments a like.