|Title||How does pressure within a tumour affect the outcome of cancer treatment?|
|Presenter||Adrianne Jenner (The University of Sydney)|
Interstitial pressure or elevated pressure within tumours has been identified as one of the major culprits impeding effective cancer treatments such as immunotherapy. Tumour pressure is known to cause heterogeneous intratumoural distribution of cancer treatments and increase the metastatic potential of tumours. Reducing tumour pressure has been shown experimentally to enhance the uptake of therapies as well their homogeneous distribution. So how instrumental is tumour pressure in reducing treatment efficacy? In this work we model the spatial distribution of treatment and the effect of pressure on treatment diffusibility. We use an off-lattice agent based approach to model this problem. Investigations are undertaken into the optimisation potential of pressure reducing treatments combined with alternate treatment application profiles to discern how to enhance homogeneous treatment diffusion without allowing the formation of metastasis. This work addresses an area possibly lacking in investigation and through deriving an appropriate mathematical model we show the impact of tumour pressure on immunotherapy and cancer treatments a like.
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