|Title||Modelling diffusion of anti-cancer viruses in solid tumours|
|Presenter||Pantea Pooladvand (The University of Sydney)|
One of the biggest barriers in treating solid tumours is the inability of therapeutic vectors to propagate throughout the tumour mass due to the high density of the tumour and tumour stroma. The dense nature of many solid tumours can be attributed to an over-expression of a collection of molecules known as the extracellular matrix (ECM). This thick and compact structure acts as a physical barrier for many treatments by shielding the malignant cells and reducing drug penetration and efficacy. One method, used to tackle the lack of diffusion of therapeutic vectors, is by treating the tumour with an oncolytic adenovirus as they are incredibly small and should be able to diffuse more efficiently throughout the tumour mass. However, biologist find that treatment with oncolytic viruses still lacks diffusion and penetration in solid tumours. In this presentation, we model the interaction between the ECM and the virus population using a lattice ODE network designed to estimate a PDE system. We ask the question: how does the ECM affect the diffusion of the virus?
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