Details of talk
|Title||Physiologically based modelling of sleep and alertness|
|Presenter||Svetlana Postnova (The University of Sydney)|
Sleep is essential for human health, well-being, and performance. However, disturbances of sleep due to shiftwork, sleep disorders, and chronic sleep restriction are very common, affecting up to 45\% of adult Australians. Reduced alertness is one of the immediate consequences of sleep disturbances associated with reduced productivity and high risk of accidents both at a workplace and on the roads. We have developed a physiologically based mathematical model of sleep-wake cycles to (i) better understand the mechanisms, (ii) enable prediction of alertness under real-world conditions; e.g. during shiftwork, and (iii) design interventions to improve alertness and sleep. The model is based on a neural mass approach simulating the mean electrical activity of neuronal populations with a set of ordinary differential equations. The model parameters are constrained by experimental data with some having measurable physiological counterparts. Results on modelling propensity to sleep, effects of light on sleep-wake cycles, and alertness dynamics under sleep deprivation and shiftwork will be presented.